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KMID : 1161420200230020173
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Journal of Medicinal Food
2020 Volume.23 No. 2 p.173 ~ p.180
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Graviola Fruit Bar Added Acerola By-Product Extract Protects Against Inflammation and Nociception in Adult Zebrafish (Danio rerio)
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da Silva Larissa Morais Ribeiro
da Silva Severino Lima Jorgiane
Magalhaes Franscisco Ernani Alves
Campos Adriana Rolim
de Araujo Jose Ismael Feitosa
Batista Francisco Lucas Alves
de Araujo Sandra Maria Barbosa
de Sousa Paulo Henrique Machado
Lima Glauber Cruz
Holanda Dayse Karine Rodrigues
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Abstract
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Studies involving foods associated with pain reversal and anti-inflammatory effects using zebrafish are rarely reported in the literature. This study aimed to evaluate the effect of graviola (Annona muricata L.) fruit bar (GFB) and GFB added with acerola (Malpighia glabra L) seed extract (ASE) on acute nociception and abdominal inflammation in adult zebrafish (Danio rerio). Acute nociception was induced by formalin, capsaicin, cinnamaldehyde, acidic saline, glutamate (cutaneous models), and hypertonic saline (corneal model), and inflammation was induced by carrageenan. Both GFB and ASE exhibited antinociceptive effect modulated by the nitrergic system, guanylate cyclase, and transient receptor potential ankyrin 1 and acid-sensing ion channels. The antinociceptive effect of GFB also appears to be modulated by the opioid system and glutamatergic receptors (N-methyl-D-aspartate receptor). Only ASE presented corneal antinociceptive effect. Both samples showed anti-inflammatory effect, being more significant the effect of GFB. The addition of acerola by-product extract in GFB results in a product with greater biological potential.
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KEYWORD
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adult zebrafish (Danio rerio), Annona muricata L., inflammation, Malpighia glabra L., nociception
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